BY EMILY WALTZ
After a decade of fighting for regulatory approval and public acceptance, a biotechnology firm has released genetically engineered mosquitoes into the open air in the United States for the first time. The experiment, launched this week in the Florida Keys — over the objections of some local critics — tests a method for suppressing populations of wild Aedes aegypti mosquitoes, which can carry diseases such as Zika, dengue, chikungunya and yellow fever. Continue Reading →
BY PAUL RINCON BBC SCIENCE
Two scientists have been awarded the 2020 Nobel Prize in Chemistry for developing the tools to edit DNA. Emmanuelle Charpentier and Jennifer Doudna are the first two women to share the prize, which honours their work on the technology of genome editing. Their discovery, known as Crispr-Cas9 “genetic scissors”, is a way of making specific and precise changes to the DNA contained in living cells. They will split the prize money of 10 million krona (£861,200; $1,110,400). Biological chemist Pernilla Wittung-Stafshede, commented: “The ability to cut DNA where you want has revolutionised the life sciences.” Continue Reading →
BY MICHAEL MARSHALL
Researchers led by Shan-Lu Liu at the Ohio State University say there is “no credible evidence” of genetic engineering. The virus’s genome has been sequenced, and if it had been altered, we would expect to see signs of inserted gene sequences. But we now know the points that differ from bat viruses are scattered in a fairly random way, just as they would be if the new virus had evolved naturally. Continue Reading →
BY MATT DAVIS
All salamanders are gifted at regeneration, but the axolotl takes this capability to the extreme. In addition to growing back its limbs, axolotl can grow back organs like their eyes and even their brains. Continue Reading →
An Osaka University team said it has carried out the world’s first transplant of cardiac muscle cells created from iPS cells in a physician-initiated clinical trial. Continue Reading →
BY HARMEET KAUR
About 15 years ago, an Amish family in the eastern US was hit by an unexplainable tragedy — one of their children died suddenly while playing and running around. Just a few months later, the same fate befell another one of their children. Continue Reading →
BY HEIDI LEDFORD
The prospect of using the popular genome-editing tool CRISPR to treat a host of diseases in people is moving closer to reality.
Medical applications of CRISPR–Cas9 had a banner year in 2019. The first results trickled in from trials testing the tool in people, and more trials launched. In the coming years, researchers are looking ahead to more sophisticated applications of CRISPR genome editing that could lay the foundation for treating an array of diseases, from blood disorders to hereditary blindness. Continue Reading →
BY JENNA MCLAUGHLIN AND ZACH DORFMAN
YAHOO NEWS EXCLUSIVE
The Pentagon is advising members of the military not to use consumer DNA kits, saying the information collected by private companies could pose a security risk, according to a memo co-signed by the Defense Department’s top intelligence official. Continue Reading →
BY EMILY MULLIN
MEDIUM / ONE-ZERO
Around this time last November, Chinese scientist He Jiankui stunned the world when he revealed the birth of the first known gene-edited babies. Working in relative secrecy, he had used CRISPR to modify human embryos in the lab and then established pregnancies with those embryos. Twin girls with edited genomes were born as a result.
The scientific community’s condemnation of He was harsh and swift. He had edited the germline, making a heritable genetic change. There were safety questions about the effects on the twins, and he had not meant to fix a genetic defect or prevent disease. Instead, he tweaked a gene in an attempt to bestow an uncommon, protective genetic trait: resistance to HIV.
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BY ROBERT F SERVICE
Synthetic biologists have performed a biochemical switcheroo. They’ve re-engineered a bacterium that normally eats a diet of simple sugars into one that builds its cells by absorbing carbon dioxide (CO2), much like plants. The work could lead to engineered microbes that suck CO2 out of the air and turn it into medicines and other high-value compounds. Continue Reading →